Work

Uncatalyzed aerobic epoxidation of liquid alkyl alkenes

Year: 2025

Type: article

Abstract: and heating between 100 and 200 °C. The reaction can be performed in either an autoclave, a stirring vessel with air bubbling or even a simple open flask, provided that any metal piece is not in contact with the reaction. Alkyl epoxides are directly obtained, after air venting, in yields and selectivity up to 90%. The simplicity of the set-up (just the neat liquid alkene and air) allows to engage the epoxidation reaction with either a previous alkene formation (upstreaming) or a later epoxide opening (downstreaming) reactions, to achieve a variety of industrially-relevant organic products in one-pot.

Source: Nature Communications

DOI: 10.1038/s41467-025-61711-3

Authors: Susi Hervàs-Arnandis, Francisco Garnes-Portolés, Silvia Rodríguez-Nuévalos, Judit Oliver-Meseguer, Antonio Leyva-Pérez

Institutions: Consejo Superior de Investigaciones Científicas, Instituto de Tecnología Química, Universitat Politècnica de València

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $6,990

Funders: Generalitat Valenciana, Universitat Politècnica de València, Agencia Estatal de Investigación, Agència Valenciana de la Innovació