Work

Mechanical stretch promotes sustained proliferation and inflammation in developing human airway smooth muscle

Year: 2025

Type: article

Abstract: Mechanical stretch associated with respiratory support can impair airway development and function in neonates, but the mechanisms are not fully understood. Using developing human airway smooth muscle cells exposed to cyclic forces with static stretch to mimic continuous positive airway pressure, we found that stretch dysregulates long-term cell proliferation and inflammatory cytokine production, and mechanosensitive Piezo ion channels may play a role in the proliferation response.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00070.2025

Authors: Li Y. Drake, Daniel Pfeffer-Kleemann, Emily Y. Zhang, Maunick Lefin Koloko Ngassie, Christina M. Pabelick, Y. S. Prakash

Institution: Mayo Clinic

Language: English

Topic: Neonatal Respiratory Health Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute