Titanium dioxide (TiO2) nanoparticles as carriers of Polygonum cuspidatum root hydroalcoholic extract: physicochemical, structural, and anticancer properties
Year: 2025
Type: article
Abstract: In this study, we developed titanium dioxide nanoparticles loaded with polyphenols from a hydroalcoholic extract of Polygonum cuspidatum (TiO 2 NPs-loaded EPc), and characterized their physicochemical properties, microstructure, and anticancer properties. The TiO 2 NPs-loaded EPc exhibited a spherical morphology with smooth surfaces and an average particle size from 23.2 to 25.4 nm. In aqueous media, the particle size increased, reaching a mean hydrodynamic diameter of 298.8 and 461 nm with a polydispersity index of 0.320 and 0.574 for TiO 2 NPs-loaded EPc R 2:1 and R 1:1 , respectively, as determined by dynamic light scattering (DLS) analysis. FT-IR and XRD analysis confirmed that incorporation of the ethanolic extract did not alter the functional groups or crystallinity of the TiO 2 NPs. The TiO 2 NPs-loaded EPc exhibited dose-dependent cytotoxicity against Caco-2 cells, with IC 50 values of 25.8 ± 6.1 µg/ml and 34.3 ± 7.1 µg/ml for TiO 2 NPs-loaded EPc R 1:1 and R 2:1, respectively. These findings suggest that TiO 2 NPs have potential as carriers of bioactive compounds for anticancer treatment.
Source: Discover Materials
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,590
OpenAlex ID: W4412481462