Work

Palladium‐Catalyzed Gem ‐Diborylalkylation of Silyl Enol Ethers and N ‐Vinylacetamide via Diboryl Carbon‐Centered Radicals

Year: 2025

Type: article

Abstract: Herein, a palladium-catalyzed coupling of gem-iododiborylalkanes with electron-rich olefins to access β,β-diboryl ketones and aldehydes under mild conditions is reported. This method exhibits broad substrate scope and excellent functional group tolerance. Mechanistic studies support a distinctive pathway involving gem-diboryl carbon-centered radicals and a Pd(0)/Pd(I) catalytic cycle, without the formation of Pd(II) intermediates. This protocol provides a new platform for accessing synthetically valuable gem-diboryl carbonyl compounds and expands the reactivity profile of organoboron-based radical transformations.

Source: Advanced Science

DOI: 10.1002/advs.202508566

Authors: Xiao‐Yu Xie, Yi Wei, Xin‐Yi Chen, Ming Li, Kai Hong

Institution: East China Normal University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $6,730

Funders: National Natural Science Foundation of China, East China Normal University