[Therapeutic mechanism of hederagenin, an active component in Guizhi Fuling Pellets, against cervical cancer in nude mice].
Year: 2025
Type: other
Abstract: OBJECTIVES: (GZFL) Pellets against cervical cancer. METHODS: Pellets. The inhibitory effects of hederagenin, an active ingredient in GZFL Pellets, was tested in cultured cervical cancer cells and in nude mice bearing cervical cancer xenografts. RESULTS: and significantly reduced STAT3 phosphorylation level in the cancer cells. In nude mice bearing cervical cancer xenografts, hederagenin effectively inhibited tumor growth rate without causing obvious adverse effects. CONCLUSIONS: GZFL Pellets inhibit cervical cancer cell growth through its multiple active components that target different pathways. Among these components, hederagenin inhibits tumor cell growth possibly by directly binding to JAK2 protein to inhibit STAT3 phosphorylation.
Source: PubMed
Authors: Yinfu Zhu, Yiran Li, Yi Wang, Yinger Huang, Kunxiang Gong, Wenbo Hao, Lingling Sun
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Award: G7871676098
OpenAlex ID: W4412487850