[Gandou Fumu Decoction improves liver steatosis by inhibiting hepatocyte ferroptosis in mice with Wilson's disease through the GPX4/ACSL4/ALOX15 signaling pathway].
Year: 2025
Type: other
Abstract: OBJECTIVES: Decoction (GDFMD) for improving Wilson's disease (WD) in tx-J mice. METHODS: , MDA, ROS, SOD, GSH and 4-HNE levels were analyzed to assess oxidative stress. RESULTS: , MDA and ROS, increased SOD and GSH levels, and reversed the changes in hepatic protein expressions. CONCLUSIONS: GDFMD improves liver steatosis in mouse models of WD possibly by inhibiting hepatocyte ferroptosis through the GPX4/ACSL4/ALOX15 signaling pathway.
Source: PubMed
Authors: Mengying Zhang, Chenling Zhao, Liwei Tian, Guofang Yu, Wenming Yang, Ting Dong
Institution: Anhui University of Traditional Chinese Medicine
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4412488998