[Forensic performance and genetic background analyses of Guizhou Chuanqing population using a self-constructed microhaplotype panel].
Year: 2025
Type: other
Abstract: OBJECTIVES: To investigate the ethnic origin of Chuanqing people, one of the largest unidentified ethnic groups in Guizhou, China, and analyze its genetic relationships with surrounding populations. METHODS: Based on a self-developed microhaplotype system, we conducted genotyping and analyzed the genetic distribution of microhaplotype loci and their forensic applicability in Chuanqing population in Guizhou Province. Using the microhaplotype data from different intercontinental populations and previously reported data from Han population living in Guizhou Province, we systematically investigated the genetic background of Chuanqing people through population genetic approaches, including genetic distance estimation, principal component analysis, and phylogenetic tree construction. RESULTS: , respectively. Population genetic analyses revealed that the Chuanqing population had close genetic relationships with the East Asian populations, especially the local Guizhou Han population, Beijing Han population and the Han populations living in southern China. CONCLUSIONS: The 33 microhaplotypes exhibit high levels of genetic diversity in the Guizhou Chuanqing population, highlighting their potentials for both forensic identification and parentage testing. The Han populations might have contributed a significant amount of genetic material to the Chuanqing population during the formation and development of the latter.
Source: PubMed
Authors: Hongling Zhang, Changyun Gu, Qiyan Wang, Xiaolan Huang, Qianchong Ran, Zheng Ren, Yubo Liu, Yansha Luo, Shuaiji Pan, Meiqing Yang, Jingyan Ji, Xiaoye Jin
Institution: Guiyang Medical University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Award: G8988484489
OpenAlex ID: W4412489262