Nodular Histiocytic/Mesothelial Hyperplasia – not such a rare phenomenon in children with Spontaneous Pneumothorax
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Primary spontaneous pneumothorax (PSP) is a relatively rare condition in children, posing significantchallenges in its management and complicating efforts to identify those at higher risk of complications. Recent studieshave drawn attention to Nodular Histiocytic/Mesothelial Hyperplasia (NHMH) as an occasionally observed histologicalchange in this patient group. Differentiating NHMH from other potential neoplastic processes has become essential toensure accurate diagnosis and appropriate treatment.Aim: This study aimed to evaluate the frequency and clinical relevance of NHMH in pediatric patients with spontaneous pneumothorax at the Department of Pediatric Surgery in Cracow, Poland.Materials and methods: We conducted a retrospective re-analysis of histological images from patients who underwentsurgery for spontaneous pneumothorax between 2012 and 2024.Results: Our findings revealed a higher incidence of NHMH in patients who required reoperation after initial pneumothoraxtreatment.Discussion: The presence of NHMH, particularly in these cases of reoperation, suggests that chronic irritation of lung tissue, possibly due to the presence of emphysematous bullae, plays a significant role in its development.Conclusions: Recognizing NHMH in these patients is crucial for preventing misdiagnosis as a neoplastic process, which can have serious clinical implications.Significance for the field: Understanding this histological feature is important for guiding future therapeutic decisions andavoiding unnecessary interventions.
Source: Polish Journal of Surgery
Institutions: Jagiellonian University, Uniwersytecki Szpital Dziecięcy
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4412491999