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Serum Progranulin as a Potential Diagnostic Predictor in Neonatal Sepsis

Year: 2025

Type: article

Abstract: Background: The study aimed to evaluate the diagnostic and prognostic power of progranulin (PGRN) in neonatal sepsis. Methods: We enrolled 67 newborns hospitalized for sepsis or suspected infection. Serum biomarkers, including PGRN, were quantified at admission. The relationship between PGRN levels and sepsis severity, hospital stay duration, and diagnostic accuracy was analyzed. Results: Neonates with sepsis exhibited elevated PGRN concentrations, which correlated directly with prolonged hospitalization. PGRN emerged as a robust prognostic biomarker for neonatal sepsis, indicating the highest predictive power (AUC: 0.956; 95% CI: 0.875-0.991; P < 0.001). At a threshold of 80.4 ng/mL, PGRN achieved 90.91% sensitivity, 80.3% specificity, and an AUC of 0.760. Conclusion: This study indicated that PGRN may be an excellent biomarker for early diagnosis and guiding clinical management of neonatal sepsis.

Source: Cureus

DOI: 10.7759/cureus.88360

Authors: Dandan Bei, Yan Cheng, Ruoxuan Jiang, Huafeng Wang

Institutions: Anhui Medical University, Second Affiliated Hospital of Anhui Medical University

Language: English

Topic: Neonatal and Maternal Infections

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4412495111