Exploring the Mechanism of Amygdala Volume Change in Patients with Bipolar Disorder at Different Stages
Year: 2025
Type: article
Abstract: Bipolar disorder (BD) is a chronic, relapsing psychiatric condition marked by recurrentepisodes of mania or hypomania and depression. It is primarily divided into Type I, Type II, and cyclothymia disorder. This paper employs a literature review method to explore the mechanisms behind the differences in amygdala volume changes in patients with bipolar disorder (BD) at different stages. By comparing the increased amygdala volume in newly diagnosed BD patients with the decreased volume in long-term BD patients, the study aims to uncover the underlying mechanisms. The article will delve into the changes in amygdala volume from three perspectives: neuroinflammation, dysregulation of the BDNF-TrkB signaling pathway, and the effects of lithium salts. The study concludes that BD patients at different stages exhibit distinct influences on amygdala volume changes in neuroinflammation, dysregulation of the BDNF-TrkB pathway, and the effects of lithium salts.
Source: Theoretical and Natural Science
Author: Yuezhen Wu
Institution: Shaanxi University of Chinese Medicine
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4412495275