Work

Local excision and secondary intention healing combined with photodynamic therapy for periocular basal cell carcinoma

Year: 2025

Type: article

Abstract: OBJECTIVE: To evaluate the efficacy of combining Local excision and secondary intention healing with photodynamic therapy (PDT) in treating periocular basal cell carcinoma (pBCC). METHODS: Clinical data from 5 pBCC patients treated between 2022 and 2023 were retrospectively analyzed. After local tumor excision, immediate intraoperative PDT was administered, followed by wound management via secondary intention healing and weekly PDT sessions. RESULTS: Complete lesion clearance was achieved in all 5 cases of pBCC, with favorable cosmetic outcomes. During a follow-up period of 18-39 months (mean 25 months), no recurrence was observed. CONCLUSION: The combined protocol minimizes the surgical defect size, simplifies post-procedural reconstruction, and enhances tumor clearance rates. It is particularly suitable for patients with BCC located in anatomically critical regions such as the periocular area, where traditional surgical excision is not amenable.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.104732

Authors: Jing Peng, Honghong Yang, Chengcheng Xiong, Xianfeng Fang, Decheng Wang

Institutions: China Three Gorges University, Yichang Central People's Hospital

Language: English

Topic: Nonmelanoma Skin Cancer Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,610