Work

Magnesium-catalyzed hydrophosphination of alkenes and alkynes

Year: 2025

Type: article

Abstract: The hydrophosphination of alkenes and alkynes catalyzed by simple commercially available magnesium reagent was reported. A range of alkenes were converted to the corresponding anti -Markovnikov alkylphosphine products in high yields and high regioselectivity under the presence of 10 mol% Grignard reagent MeMgI at room temperature. Meanwhile, the hydrophosphination of various alkynes was catalyzed by 10 mol% n Bu 2 Mg to afford the corresponding anti -Markovnikov Z -alkenylphosphines with high yields and excellent regioselectivity. Scale-up reaction show great potential in practical applications.

Source: Tetrahedron

DOI: 10.1016/j.tet.2025.134849

Authors: Yongxin Feng, Xiaofei Rong, Xuguang Zhang, Yukang He, Mengtao Ma

Institution: Nanjing Forestry University

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,680

Funder: National Natural Science Foundation of China