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A Rare Case of Pneumomediastinum and Subcutaneous Emphysema Secondary to Recreational Nitrous Oxide Inhalation

Year: 2025

Type: article

Abstract: The recreational inhalation of nitrous oxide, also known as laughing gas, continues to rise due to its euphoric effects and easy accessibility. Clinicians may therefore encounter patients suffering from the potential adverse effects of nitrous oxide inhalation more commonly. We present a case of a 35-year-old man who presented with neck and facial swelling and pleuritic chest pain after a two-day recreational binge of nitrous oxide inhalation. The patient was found to have subcutaneous emphysema and pneumomediastinum, rare adverse effects of nitrous oxide inhalation. The patient's symptoms improved with supportive care.

Source: Cureus

DOI: 10.7759/cureus.88331

Authors: Nicole C Oparaugo, Jay Cadavona, Sean D Delshad

Institutions: University of California, Irvine, University of California, Los Angeles

Language: English

Topic: Pneumothorax, Barotrauma, Emphysema

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4412501636