Association between the dietary index for gut microbiota and metabolic syndrome: the mediating role of the dietary inflammatory index
Year: 2025
Type: article
Abstract: Background: Metabolic syndrome (MetS) poses a huge global public health challenge. The dietary index for gut microbiota (DI-GM) measures the influence of diets on the microbiome, but its link with the odds of MetS is elusive. This paper examined the link between DI-GM and MetS and investigated the mediating role of the dietary inflammatory index (DII). Methods: Data were sourced from the 2007-2018 NHANES for adults diagnosed with MetS. A total of 20,999 participants were included in the analysis. Dietary data were recorded via two 24-h dietary recalls, from which DI-GM and DII were calculated. Multivariate weighted logistic regression and restricted cubic spline (RCS) analyses were leveraged to assess the link between DI-GM and MetS. Mediation analysis was implemented to determine the role of DII in this association. Subgroup and sensitivity analyses were also implemented. Results: < 0.001]. Subgroup analysis showed consistent negative associations between higher DI-GM (Q4) and MetS across various demographic and lifestyle subgroups, with no statistically significant interactions observed (P interaction > 0.05). Conclusion: High DI-GM levels are linked with a significantly reduced odds of MetS, with DII partially mediating this association.
Source: Frontiers in Nutrition
Authors: Yu-Nan Han, Yong-Xiang Wang, Cheng-Yue Xiong, Lin Li, Ru-Meng Mao
Institution: Yangtze University
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4412506033