Work

Figure 1 from Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer

Year: 2025

Type: other

Abstract: MPZL3 expression in ovarian cancer tissues. A, Percentage of tumor samples displaying MPZL3 CNA based on International Cancer Genome Consortium/TCGA pan-cancer analysis of whole genomes. B, MPZL3 mRNA expression and MPZL3 CNA in ovarian adenocarcinoma samples (TCGA, PanCancer Atlas). C, MPZL3 methylation is negatively associated with MPZL3 mRNA expression (TCGA, PanCancer Atlas). D, MPZL3 transcript levels detected by semi-quantitative RT-PCR in high-grade serous ovarian (T-OV, n = 11) and omental tumors (T-OM, n = 8) compared with normal fallopian tube tissues (N-FT, n = 14; Kruskal–Wallis multiple comparison test P = 0.07; Dunn multiple comparison test P values shown). HOMDEL, deep deletion; HETLOSS, shallow deletion.

DOI: 10.1158/2767-9764.29607321

Authors: Ya-Yun Cheng, Beth L. Worley, Zaineb Javed, Amal T. Elhaw, Priscilla W. Tang, Sarah Al-Saad, Shriya Kamlapurkar, Sierra R. White, Apoorva Uboveja, Karthikeyan Mythreye, Katherine M. Aird, Traci A. Czyzyk, Nadine Hempel

Language: English

Topic: Ovarian cancer diagnosis and treatment

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4412506604

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