Evaluation of pulmonary perfusion and ventilation in suspected chronic thromboembolic pulmonary hypertension via phase-resolved functional lung magnetic resonance imaging: correlations with hemodynamics and cardiopulmonary function
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Phase-resolved functional lung (PREFUL) magnetic resonance imaging (MRI) is a reliable, noninvasive method for assessing pulmonary ventilation and perfusion. However, the differences in subgroups of patients with chronic pulmonary embolism (CPE) have not been thoroughly investigated, and there may be significant clinical value in examining noninvasive methods for evaluating hemodynamics and right heart function in patients with CPE. This study aimed to evaluate pulmonary perfusion and ventilation in patients with suspected chronic thromboembolic pulmonary hypertension (CTEPH) via PREFUL MRI and further determined the correlations of these findings with right heart catheterization (RHC), right heart function indicators, and pulmonary function test results. Methods: ). Clinical correlations were assessed through the comparison of PREFUL MRI parameters with hemodynamic data, right heart function indicators, and pulmonary function parameters. Results: was negatively correlated with the ratio of forced expiratory volume in 1 s to forced vital capacity (parameter expressed as a percentage of the predicted value) (r=-0.379; P=0.027). Conclusions: Quantitative parameters obtained from PREFUL MRI were correlated with hemodynamic status and cardiopulmonary function in patients with CTEPH or CTED. PREFUL MRI perfusion parameters demonstrated strong diagnostic performance for CTEPH, indicating their clinical potential.
Authors: Jianghui Duan, Liangying Liu, Sijia Guo, Hongliang Sun, Min Liu, Jing An, Robert Grimm, Andreas Voskrebenzev, Jens Vogel-Claussen, Sheng Xie
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412508055