Synthesis, Characterization, and Catalytic Application of Novel Magnetically Separable Fe 3 O 4 @SiO 2 ‐Pr‐NH‐TDI‐VB1 for Rapid Synthesis of Hydrazinyl Thiazoles
Year: 2025
Type: article
Abstract: ABSTRACT In this work, we report novel thiamine hydrochloride functionalized magnetic nanoparticles (Fe 3 O 4 @SiO 2 ‐Pr‐NH‐TDI‐VB1) for catalytic applications. The catalytic potential of Fe 3 O 4 @SiO 2 ‐Pr‐NH‐TDI‐VB1 was assessed in the one‐pot three‐component reaction of phenacyl bromide, thiosemicarbazide, and aryl aldehyde for the synthesis of hydrazinyl thiazole in EtOH:H 2 O (50:50, v/v ) at room temperature. The present method exhibits the advantages of a simple reaction procedure, reduced reaction time, efficient retrieval of catalyst for the five runs using an external magnet, ambient reaction condition, and excellent yields. The resultant hydrazinyl thiazoles were purified by simple recrystallization using ethanol.
Source: Applied Organometallic Chemistry
DOI: 10.1002/aoc.70299
Authors: Reshma Yadav, Rutuja Zond, Vishvjeet Havaldar, Sakshi Mane, Unnati Sasane, Bhaveshwari Budake, Sandeep Sankpal, Shankar Hangirgekar
Institution: Shivaji University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Awards: G2045158288, G6334714091, G8141756407
OpenAlex ID: W4412508928