Work

Trevesia palmata -derived terpenoid-rich silver nanoparticles induce apoptosis and upregulate p21/CAV1 proteins in gastric cancer cells

Year: 2025

Type: article

Abstract: ). Flow cytometry revealed dose-dependent apoptosis in MKN45 cells induced by Trp-AgNPs. Trp-AgNPs upregulated the transcription of Caspase 8, Caspase 3, P21, and Caveolin-1 (CAV1) genes. Significantly, the mRNA expression of P21 increased by more than five-fold, while CAV1 demonstrated an approximately eleven-fold increase, indicating their potential role in cytotoxicity. Additionally, strong binding of nanoparticle surface compounds to anti-apoptotic proteins, as shown by molecular docking, reveals how Trp-AgNPs induce apoptosis signaling in gastric cancer cells. These findings highlight the potential of Trp-AgNPs as a targeted, eco-friendly therapeutic strategy for gastric cancer.

Source: RSC Advances

DOI: 10.1039/d5ra03268g

Authors: Van Hung Hoang, Thi Thanh Huong Le, Thi Tam Khieu, Thi Ngoc Thuy Le, Thi Kieu Oanh Nguyen, Phu Hung Nguyen

Institutions: Thai Nguyen University, Trường Đại học Khoa học

Language: English

Topic: Nanoparticles: synthesis and applications

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042