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The role of environmental heavy metals and the risks for autoimmunity and related rheumatic diseases

Year: 2025

Type: article

Abstract: Heavy metal exposure has been associated with the development of autoimmune rheumatic diseases in susceptible individuals.We briefly reviewed the cellular and molecular mechanisms by which metals can affect auto proteins and convert them into neoantigens and analyse the potential integrin-dependent signalling pathways that result in the production of inflammatory cytokines and autoantibodies.We critically assess autoimmunity related to heavy metal exposure.We also discuss environmental measures to prevent environmental pollution and conclude that heavy metal environmental pollution is an unacceptable, yet preventable, problem.

Source: Journal of Environmental Rheumatology

DOI: 10.55563/jer/7zzcoa

Authors: Rafael Herrera-Esparza, Esperanza Avalos-Díaz, Roxana Ramírez-Sandoval, Juan-José Bollain-y-Goytia-de-la-Rosa

Institution: Universidad Autónoma de Zacatecas "Francisco García Salinas"

Language: English

Topic: Heavy Metal Exposure and Toxicity

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4412513970