Year: 2025
Type: editorial
Abstract: This editorial challenges the long-held neuron-centered view of brain metabolism, relying on ample evidence that it is a cooperative, multicellular process. Astrocytes, oligodendrocytes, and other glia play active roles providing lactate, antioxidant support, and substrate shuttles that fuel neuronal function and memory. Despite mounting data, some critics persist in refuting intercellular metabolic exchange, often guided more by entrenched creeds than concrete evidence, slowing constructive, hypothesis-driven discourse and delaying clinical and neuroprotective advances. The authors call for a rigorous research agenda: cell-type-specific manipulations, advanced biosensors, imaging and biomarkers, and integration with behavior and electrophysiology. They urge redirecting focus from outdated dogma to physiology-driven exploration of glia-neuron metabolic partnerships.
Source: Journal of Neurochemistry
DOI: 10.1111/jnc.70166
Authors: Juan P. Bolaños, Cristina M. Alberini, Angeles Almeida, L. Felipe Barros, Gilles Bonvento, Anne‐Karine Bouzier‐Sore, Ralf Dringen, Giles E. Hardingham, Johannes Hirrlinger, Pierre J. Magistretti, Giovanni Marsicano, Klaus‐Armin Nave, Rosa C. Paolicelli, Luc Pellerin, Pierre‐Yves Plaçais, Thomas Preat, Nathalie Rouach, Ivan Ruminot, Aiman S. Saab, Carmen Sandi, Stefanie Schirmeier, Avital Schurr, Jimena Sierralta, Maite Solas, Vanja Tepavcevic, Bruno Weber, Eduardo R. Zimmer
Institutions: Consejo Superior de Investigaciones Científicas, Universidad de Salamanca, Instituto de Biología Funcional y Genómica, New York University, Universidad San Sebastián, Centro de Estudios Científicos, Centre National de la Recherche Scientifique, Université Paris-Saclay, Institut des Neurosciences Paris-Saclay, Centre de Résonance Magnétique des Systèmes Biologiques, University of Bremen, Simons Initiative for the Developing Brain, University of Edinburgh, Max Planck Institute for Multidisciplinary Sciences, Leipzig University, King Abdullah University of Science and Technology, Université de Bordeaux, Inserm, Neurocentre Magendie, University of Lausanne, Université de Poitiers, Centre Hospitalier Universitaire de Poitiers, Université Paris Sciences et Lettres, Laboratoire Plasticité du Cerveau, ESPCI Paris, Collège de France, Centre Interdisciplinaire de Recherche en Biologie, University of Zurich, ETH Zurich, École Polytechnique Fédérale de Lausanne, Technische Universität Dresden, University of Louisville, University of Chile, Navarre Institute of Health Research, Universidad de Navarra, Universitat de València, Universidade Federal do Rio Grande do Sul
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4412514691