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Antibacterial Activity of Polyvinylidene Fluoride/polyethylene Oxide Nanofibers Loaded with Azithromycin for Wound Dressing

Year: 2025

Type: article

Abstract: Treating skin injuries remains challenging due to issues like wound infections.In this study, polyvinylidene fluoride (PVDF)/polyethylene oxide (PEO)/azithromycin (AZ) composite nanofibers were prepared using electrospinning to reduce bacterial infections in skin wounds.The surface morphology, chemical structure, and hydrophilicity of the nanofibers were characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and contact angle measurements, respectively.Antibacterial performance tests revealed that increasing the AZ dosage expanded the antibacterial zone, indicating improved effectiveness.Furthermore, experiments on rat skin infections showed that the PVDF/PEO/AZ membrane inhibited suppuration at S. aureus-infected wound sites.These findings demonstrate the potential of AZ-loaded PVDF/PEO nanofiber membranes as effective antibacterial dressing.

Source: Materiale Plastice

DOI: 10.37358/mp.25.1.5752

Authors: SHUO WANG, XINYUAN XU, XIANGYU ZHU, DAN WANG, BEI XIE

Institutions: Shaoyang University, Central South University

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Natural Science Foundation of Hunan Province