Work

DNA/bovine serum albumin interaction studies and immunomodulatory effects of dinuclear platinum(II) complex with aromatic 1,5-naphthyridine bridging ligand

Year: 2025

Type: article

Abstract: The DNA and bovine serum albumin binding evaluation of the dinuclear platinum(II) complex, [{PtCl(NH3)2}2(?-1,5-nphe)](ClO4)2 (1,5-nphe is the bridging 1,5-naphthyridine ligand) was investigated by UV?Vis and fluorescence emission spectroscopy. Influence of platinum(II) complex on immune response was also estimated. Peritoneal splenocytes isolated from BALB/c mice were treated with Concanavalin A (ConA) and platinum(II) complex. Concentrations of IFN-?, IL-1?, IL-17, TNF-? and IL-10 were measured and immunophenotyping was performed. Results showed notable immunomodulatory effects. Pt(II) complex has an inhibitory effect on the release of proinflammatory cytokines in ConA activated splenocytes and CD3+ T cells.

Source: Journal of the Serbian Chemical Society

DOI: 10.2298/jsc250411049m