Work

Laboratory Practices for the Detection and Characterization of Cryoglobulins and Cryofibrinogen

Year: 2025

Type: article

Abstract: BACKGROUND: Cryoglobulins (CGs) and Cryofibrinogen (CF) are proteins that precipitate at low temperatures. Complex laboratory procedures are necessary to identify them. METHODS: Between December 2022 and December 2023, 1171 patient samples for analysis of CGs and CF were received in the laboratory from different clinical departments with suggestive clinical symptoms and signs of cryoproteinemia and were analyzed using pre-analytical, analytical, and post-analytical procedures. RESULTS: in 88 patients (14.9%). CONCLUSIONS: CGs testing has long been common in laboratories, and the analytical and pre-analytical procedures are well known, in contrast to CF testing, which has only emerged in recent years. Therefore, appropriate procedures are needed for testing both cryoproteins to optimize economic and human resources and reduce laboratory diagnostic times. At last, confirming a clinical suspicion of cryoproteinemia in a short time could improve patient outcomes, allowing suitable therapies to be implemented for vasculitis and related thromboembolic phenomena.

Source: Journal of Clinical Laboratory Analysis

DOI: 10.1002/jcla.70074

Authors: Teresa Troiano, Anna Marinaccio, Pamela Patierno, Alessandra Di Geronimo, Lucia Demarinis, Francesca Di Serio

Institutions: Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari, Gastroenterology Hospital "Saverio de Bellis"

Language: English

Topic: Clinical Laboratory Practices and Quality Control

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,120