Precise virulence inactivation using a CRISPR-associated transposase for combating Enterobacteriaceae gut pathogens
Year: 2025
Type: article
Source: Nature Biomedical Engineering
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: U.S. Department of Defense, U.S. Department of Health and Human Services, Burroughs Wellcome Fund, Simons Foundation, Irma T. Hirschl Trust, National Institutes of Health, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Biomedical Imaging and Bioengineering
Awards: New mechanism of commensal bacteria interaction with host immunity, Leveraging Programmable Integrases for Human Genome Engineering, G1804979653, G2905623195, Ecological dynamics and metabolic interactions in thegut microbiome across space and time, G4706590614, G4988360024, G5484572775, G5744157394, G5966001984, A high-performance and versatile technology for precision microbiome engineering, Impact of CRISPR-associated transposons on anti-phage immunity in Vibrio cholerae, G7180071988, Discovery of immunomodulatory gut microbes with MAGIC, G8372991953, G8796544252, G8889765473, Micron-scale Spatial Metagenomic Mapping of Microbial Biogeography in the Gastrointestinal Tract, ePACE: automation platforms for adaptable and scalable continuous evolution of biomolecules with therapeutic potential, Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease, The Columbia University Digestive and Liver Disease Research Center
OpenAlex ID: W4412522337