Work

Chronic circadian disruption in adolescent mice impairs hippocampal memory disrupting gene expression oscillations

Year: 2025

Type: article

Abstract: Chronodisruption, the misalignment of internal biological systems with external environmental changes, negatively impacts health and cognition. A prevalent form, social jet lag, affects a large portion of adolescents and is associated with reduced academic performance, and impaired emotional regulation. Despite its prevalence, the mechanism by which adolescent chronodisruption results in cognitive deficits remains unexplored. Here, we induced chronic chronodisruption in adolescent mice through light/dark cycle manipulation. We performed a battery of established behavioral tests alongside an analysis of daily rhythms of expression of genes involved in relevant physiological functions. We report that adolescent circadian disruption induces impairments in short-term, social, and spatial memory without prompting anxiety-like behavior. Gene expression analyses revealed altered oscillation patterns of circadian clock genes in the hypothalamus and hippocampus. Furthermore, we identified alterations in daily patterns of genes involved in glucocorticoid and endocannabinoid transmissions as well as synaptic plasticity. This work emphasizes the importance of circadian homeostasis for cognitive function and hippocampal homeostasis. Thus, understanding the mechanism underlying adolescent chronodisruption is essential to better understand its long-term implications for cognitive function and overall health.

Source: Scientific Reports

DOI: 10.1038/s41598-025-12237-7

Authors: Ines Gallego-Landin, Paula Berbegal-Sáez, Olga Valverde

Institutions: Universitat Pompeu Fabra, Hospital Del Mar, Hospital del Mar Research Institute

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690