Year: 2025
Type: article
Study design: Case Report
Abstract: An 85-year-old female patient with multiple comorbidities, including Parkinson's disease, hyperthyroidism, congestive heart failure, and Alzheimer's, presented with dyspnea, weakness, and cough. She was found to have new-onset atrial fibrillation and a left frontal lobe infarct. Initially treated with levofloxacin and then azithromycin, she later developed right lung infiltrates, and ceftriaxone 2g IV daily was initiated. Within 48 hours, liver enzymes aspartate aminotransferase (AST) and alanine transaminase (ALT) rose markedly (from 11/26 to 452/415 U/L). We promptly discontinued ceftriaxone in response and considered alternative antibiotics. The multidisciplinary team opted for supportive management with daily liver function monitoring, resulting in gradual normalization of transaminases. This case highlights the importance of prompt drug discontinuation, use of structured drug-induced liver injury (DILI) assessment tools, and adherence to geriatric prescribing guidelines.
Source: Cureus
DOI: 10.7759/cureus.88419
Authors: Allison D Zettwoch, Okelue E Okobi, Mercedes Millan, Angelica Perez Fonte, Raphael S Figueroa, Tolulope A Fatuki, Raul J De la Vega, Sergio Hernandez Borges, Miguel Diaz-Miret
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4412523731