Year: 2024
Type: conference-paper
Abstract: This work demonstrates the first example of a bioimpedance sensing ingestible device capable of feedback-driven, localized microneedle drug delivery into gastrointestinal (GI) tissue.The system integrates a thin-film, tetrapolar bioimpedance sensor with a potentiostat circuit and Bluetooth-enabled microcontroller (MCU) to trigger delivery of drug-loaded microneedles using a cantilever actuator.The sensor-driven trigger mechanism utilizes a dynamic bioimpedance threshold value, programmed via mobile phone, to initiate thermomechanical release of the drug cantilever.This behavior was validated using ex vivo small intestinal porcine tissue samples of varied conductivity, resulting in impedance-dependent delivery in ~1.59 seconds.This technology provides a foundation for rapid, localized treatment of GI disease facilitating minimally invasive oral treatment with minimal side effects.
Authors: Mateo W. Lim, Brian M., Joshua A., Justin M., Luke A., Reza Ghodssi
Institution: University of Maryland, College Park
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4412524145