Work

Strategies for Controlling Particle Size in Injectable Nanosuspensions and Emulsions: Techniques and Future Opportunities

Year: 2025

Type: article

Abstract: Particle size is crucial for injectable nanosuspensions and emulsions, significantly impacting their performance. Achieving optimal particle size is essential in parenteral formulations, and various methods and equipment are available for this purpose. For nanosuspensions, standard manufacturing techniques include ionic cross‐linking, solvent evaporation, hot homogenization, SEA‐PES, and wet milling with crystalline APIs. Nanoemulsions, on the other hand, are typically produced using homogenization and solvent evaporation. This review focuses on achieving particle sizes below 200 nm using bead milling, spray drying, microfluidics, and high‐shear homogenization techniques. In addition, sterilization of these nanoformulations can be accomplished through filtration using a 0.22 μm redundant filter and focuses on forthcoming tips on conventional methods and emerging opportunities for improving nanoformulation processes.

Source: Advances in Pharmacological and Pharmaceutical Sciences

DOI: 10.1155/adpp/3632073

Authors: Dileep J. Babu Bikkina, Rajesh Vooturi, Subhash Zade, Narendra Reddy Tharigoppala, Suresh Kumar Joshi, Gundawar Ravi

Institution: Manipal Academy of Higher Education

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000