Site-dependent modulation of antitumor activity and fluorescence in thieno[3,2- b ]pyridin-5(4 H )-ones
Year: 2025
Type: article
Abstract: )-one scaffold are dependent on the aryl substitution site. Specifically, 3-aryl derivatives exhibited notable antitumor activity, whereas 2-aryl analogues displayed strong fluorescence, highlighting the potential of this scaffold for dual-function applications. DFT calculations supported the observed divergence in fluorescence by revealing differences in orbital conjugation and HOMO-LUMO gaps. In addition, selected compounds showed low cytotoxicity toward MRC-9 cells, indicating favourable cancer cell selectivity.
Source: RSC Medicinal Chemistry
DOI: 10.1039/d5md00399g
Authors: Dan-Bi Sung, Pham Van Thong, Jieun Yun, Joo-Hee Kwon, Sol Park, Sang Kook Woo, Jong Soon Kang, Jong Seok Lee
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Award: G7601308199
OpenAlex ID: W4412525328