Year: 2025
Type: article
Abstract: ABSTRACT Although the presence of synchronous colorectal liver metastases (CRLM) represents an important prognostic factor for recurrence-free survival (RFS) and overall survival (OS), the definitions of synchronicity are variable in the literature, including metastases at the time of diagnosis, or even before the diagnostic of the primary site of colorectal cancer (CRC), until either six or 12 months after the time of diagnosis, according to the author of each study. Simultaneous approaches to treat CRC and CRLM seem to be safe for patients carefully selected without jeopardizing oncologic outcomes, with similar complication rates, shorter hospital length of stay, and operation times even for major hepatectomies. However, there is no consensus about the optimal timing to approach the primary tumor and CRLM, whether simultaneously or staged, and both performance status and the presence of symptoms play important roles in the treatment sequence, perhaps avoiding two high-risk procedures at the same time.
Authors: Raphael Leonardo Cunha ARAUJO, Marcelo Moura LINHARES, Antonio Roberto Franchi TEIXEIRA, Aleksandar KARAMARKOVIC, Hugo Pinto MARQUES, Timothy M. PAWLIK, Rene ADAM, Olivier SOUBRANE, Maria Ignez BRAGHIROLI, Paulo HERMAN, Ricardo Lemos COTTA-PEREIRA
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412528119