Year: 2025
Type: article
Study design: Observational Study
Abstract: In Chronic Lymphocytic Leukemia (CLL), t(14;19)(q32;q13), leading to the overexpression of BCL3, is found in ∼1% of cases and is associated with an aggressive disease. In this study, leveraging a large CLL patient cohort collected thanks to an international collaboration, we investigate for the first time the circular transcriptome (circRNAome) associated with the rare t(14;19), in comparison with CLL without t(14;19) and B cells of age-matched healthy donors. We described the circRNAs commonly dysregulated in CLL, including circCSNK1G3 and circEXOC6B(3–5), which were depleted, and circZNF609 and circLPAR3, which were overexpressed in malignant cells. Of importance, we disclosed the circRNA signature of CLL with t(14;19), formed by circRNAs with expression significantly altered specifically in link with this lesion, ectopically expressed like circCDK14(3–4), circCORO1C, circCLEC2D, and circEMB, or downregulated like circCEP70(3–6). Several of these molecules were previously shown to be dysregulated or play a role in cancer, whereas most of the signature circRNAs deserve further investigation. CLL patients with high circCORO1C and circCLEC2D expression had significantly worse clinical outcomes, with shorter time to first treatment and overall survival. This study disclosed new molecular features of the aggressive CLL subtype with t(14;19).
Source: Journal of Hematology & Oncology
Authors: Eleonora Roncaglia, Enrico Gaffo, Giulia Calabretto, Moritz Fürstenau, Kerry A. Rogers, Panagiotis Baliakas, Chenghua Cui, Cecelia Miller, Claudia Haferlach, Karla Plevova, David Oscier, Zadie Davis, Florence Nguyen-Khac, Gian Matteo Rigolin, Anastasia Athanasiadou, Fanny Baran-Marszak, Alberto Valiente, Maria José Terol, Pau Abrisqueta, Blanca Espinet, Anna Puiggros, Annalisa Martines, Laura Bonaldi, Francesca Romana Mauro, Lydia Scarfò, Thomas Chatzikonstantinou, Eugen Tausch, Karl-Anton Kreuzer, Arnon Kater, Francesc Bosch, Michael Doubek, Panagiotis Panagiotidis, Olga Kalashnikova, Federica Frezzato, Valeria Ruocco, Silvia Orsi, Kimia Salek, Roberto Merlo, Alberto Caregari, Ilias Glogovitis, Alessandro Cellini, Francesco Angotzi, Andrea Serafin, Shuhua Yi, Barbara Eichhorst, Jennifer A. Woyach, Antonio Cuneo, Paolo Ghia, Kostas Stamatopoulos, Livio Trentin, Andrea Visentin, Stefania Bortoluzzi
Institutions: University of Padua, University of Cologne, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Uppsala University, Science for Life Laboratory, Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Hematology & Blood Diseases Hospital, State Key Laboratory of Experimental Hematology, Munich Leukemia Laboratory (Germany), Masaryk University, University Hospital Brno, Royal Bournemouth Hospital, Pitié-Salpêtrière Hospital, University of Ferrara, Arcispedale Sant'Anna, G. Papanikolaou General Hospital, Assistance Publique – Hôpitaux de Paris, Hôpital Avicenne, Laboratoire d'hématologie, Hospital Clínico Universitario de Valencia, Vall d'Hebron Hospital Universitari, Vall d'Hebron Institute of Oncology, Hospital Del Mar, Hospital del Mar Research Institute, Istituto Oncologico Veneto, Sapienza University of Rome, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, Centre for Research and Technology Hellas, Universität Ulm, Cancer Center Amsterdam, National and Kapodistrian University of Athens, First Pavlov State Medical University of St. Petersburg
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,990
OpenAlex ID: W4412535407