Urinary and serum biomarkers of renal injury in coronary artery bypass grafting: a prospective evaluation with new biomarkers’
Year: 2025
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Cardiopulmonary bypass (CPB) for coronary artery bypass grafting (CABG) often causes kidney dysfunction and increases morbidity and mortality. AIMS: To evaluate the effects of CPB on kidney structures of patients submitted to CABG using serum and urinary biomarkers. METHODS: This prospective study included patients who underwent CABG over a 14-month period. Data related to clinical, surgical, and laboratory were collected. The glomerular filtration rate was estimated using the CKD-EPI equation. The urinary biomarkers trialed were nephrin, KIM-1, MCP-1, Syndecan-1, and NGAL. RESULTS: Out of 30 patients enrolled, 22 were assessed. The mean age was 65 years and most were male. During CABG, the On-pump group had increased urinary nephrin (p = 0.007) and urinary (p = 0.036) and serum NGAL (p = 0.030) levels compared to the Off-pump group. Moreover, intraoperatively, in the On-Pump clusters, the urinary NGAL was correlated with the decrease of glomerular filtration rate in the first 48 hours after CABG (Rho = - 0.838, p = 0.009). There was no statistical difference in clinical and surgical aspects between groups according to use of CBP during CABG. CONCLUSION: CBP procedure used during CABG was associated with relevant effects on kidney structure, such as podocyte and tubular injury. Urinary NGAL was able to predict an impairment of glomerular filtration 48 hours after CABG.
Source: Brazilian Journal of Nephrology
Authors: Simão Antônio Felipe Leite, Meneses Gdayllon Cavalcante, Cezar Lia Cavalcante, Araújo Letícia Machado de, Martins Alice Maria Costa, Filho Heraldo Guedis Lobo, Martins Bruna Viana Barroso, Júnior Geraldo Bezerra da Silva, Daher Elizabeth De Francesco, Filho José Glauco Lobo
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G233101189, G8262246763
OpenAlex ID: W4412536853