Work

Synthesis, Characterization and Biological Evaluation of Novel Macrocyclic Metal Complexes: Insights from Spectroscopic Analysis, Molecular Docking, Antioxidant Studies, and Antimicrobial Screening

Year: 2025

Type: article

Abstract: Significant contributions to the development of inorganic chemistry were made by macrocyclic complexes. It has stimulated interest in the study of macrocyclic metal ‎complexes in the design and development of novel antibiotics. In this regard, a series of nine ‎novel macrocyclic complexes of Co(II), Ni(II), and Cu(II) were synthesized by a template approach ‎in a [2:1:2] ratio utilizing o-phenylenediamine and dicarboxylic acid. The newly designed ‎complex's structure has been verified by elemental analysis, Fourier transform infrared, UV-Visible, mass spectrometry, thermogravimetric (TG) analysis, and EPR studies. The Coats-Redfern method was employed for the evaluation of various thermodynamic parameters. Based on ‎the spectral studies distorted octahedral geometry has been proposed around the central metal ion ‎in the synthesized complexes. The synthesized complexes were evaluated against Gram-positive ‎bacteria [S. aureus, B. subtilis] and Gram-negative [E. coli, P. aeruginosa] along with fungal ‎strains [C. albicans and A. niger] to assist their antimicrobial potential by agar well diffusion ‎method. Furthermore, the complexes have also been examined for their antioxidant activity ‎utilizing the DPPH assay. Subsequently, molecular docking studies were performed using the Auto ‎Dock Vina programme to assess the biological significance of the synthesized complexes and ‎determine effective binding modes between different ligands and the receptor proteins. The ‎copper macrocyclic complexes demonstrated excellent biocidal action against the selected ‎microbes. Copper acetate exhibited the highest antioxidant potential. The obtained results revealed ‎that the synthesized macrocyclic complexes are potent for making them attractive metal-based ‎antimicrobial and antioxidant prototypes‎.

Source: International Journal of Advanced Chemistry

DOI: 10.14419/xmh8yz53

Authors: Rajrani Gulia, Indu Sindhu, Anshul Singh, Neetu Patel

Institutions: Baba Mastnath University, Awadhesh Pratap Singh University

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Indian Institute of Technology Roorkee, Indian Institute of Technology Delhi