Work

Label-free biosensing of microRNA-423-5p in saliva sample of patients using KAUST catalysis center-1 modified dendritic AuNPs: a new platform towards early-stage diagnosis of oral cancer

Year: 2025

Type: article

Abstract: Au-S interaction to detect microRNA-423-5p in human saliva in low limit of quantification of 1 pM. The biosensor successfully detected microRNA-423-5p, demonstrating its potential for OC screening. The genosensor development involved assessing crucial factors such as hybridization time and microRNA concentration. Analytical techniques including cyclic voltammetry, chronoamperometry, and differential pulse voltammetry were used for quantifying MicroRNA-423-5p in human biofluids. The biosensor's performance characteristics were evaluated for stability, repeatability, and suitability for plasma and saliva samples.

Source: RSC Advances

DOI: 10.1039/d5ra03672k

Authors: Hamed Bahari, Mohammad Hasanzadeh, Soodabeh Davaran, Farzin Ahmadpour, Nasrin Shadjou

Institutions: Tabriz University of Medical Sciences, Urmia University

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042