Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Obstetric complications (OCs) are associated with cognitive and brain abnormalities observed in patients with schizophrenia. Gyrification, a measure of cortical integrity sensitive to events occurring during the prenatal and perinatal periods, is also altered in first-episode psychosis (FEP). We examined the relationship between OCs and gyrification in FEP, as well as whether gyrification mediates the relationship between OCs and cognition. Methods We examined differences in the Local Gyrification Index (LGI) for the frontal, parietal, temporal, occipital, and cingulate cortices between 139 FEP patients and 125 healthy controls (HCs). Regression analyses explored whether OCs and diagnosis interact to explain LGI variation. Parametric mediation analyses were conducted to assess the effect of LGI on the relationship between OCs and cognition for FEP and HC. Results Significant LGI differences were observed between FEP patients and HC in the left parietal and bilateral cingulate and occipital cortices. There was a significant interaction between OCs and diagnosis on the left cingulate cortex (LCC) that was specific to males (p = 0.04) and was driven by gestational rather than intrauterine OCs. In HCs, OCs had a direct effect on working memory (WM) (p = 0.048) in the mediation analysis, whereas in FEP, we observed no significant effect of OCs on either verbal or WM. Conclusions OCs interact with diagnosis to predict LCC gyrification, such that males with FEP exposed to OCs exhibit the lowest LGI. OCs influence WM, and LCC gyrification may mediate this relation only in HC, suggesting a differential neurodevelopmental process in psychosis.
Source: Psychological Medicine
Institutions: Hospital Universitario Central de Asturias, Universitat de Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universidad Complutense de Madrid, Hospital General Universitario Gregorio Marañón, Universidad Pública de Navarra (UPNA), Navarre Institute of Health Research, Hospital Del Mar, Universitat Pompeu Fabra, Hospital del Mar Research Institute, King's College London, Fidmag Sisters Hospitallers, Vall d'Hebron Institut de Recerca
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,550
Funders: Ministerio de Ciencia, Innovación y Universidades, Centres de Recerca de Catalunya, European Commission, Generalitat de Catalunya, Ministerio de Economía y Competitividad, Ministerio de Ciencia e Innovación, Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, European Regional Development Fund, H2020 Marie Skłodowska-Curie Actions
Awards: G1221314662, G1552314173, G1874133415, Biomedicine international training research programme for excellent clinician-scientists, G2375181428, G2377181310, G2620658983, Estrés prenatal y metabolismo: analizando los mecanismos moleculares en primeros episodios psicóticos - Estudio PASTIME-PEP, G2901997439, G2967983654, G3108940385, G3559709381, G3622567221, G3978511092, G434337789, G4806979115, Evolución a largo plazo, respuesta a tratamiento y recaídas de los trastornos de la compulsividad: biomarcadores neuroinflamatorios, neuropsicológicos y de neuroimagen., SchizOMICS: Estudio multidisciplinar CIBER para optimizar el tratamiento de la esquizofrenia utilizando datos multi-omics y biología de sistemas, Estudio de aplicabilidad clínica de un modelo predictivo de recaídas en primeros episodios de esquizofrenia, G6745079539, El efecto de los eventos perinatales en los primeros episodios psicoticos., G736885710, ESTUDIO MULTICÉNTRICO LONGITUDINAL SOBRE MARCADORES DE PREDICCIÓN DE LA TRANSICIÓN A PSICOSIS EN NIñOS Y ADOLESCENTES CON RIESGO DE PSICOSIS: EL PAPEL DEL ESTRÉS INTRAUTERINO, G76789454, G796096517, G8119345636, G8632328077
OpenAlex ID: W4412552254