Work

Detection and resolution of sub-millimolar concentration amino acids on a benchtop NMR spectrometer by nh-PHIP hyperpolarization

Year: 2025

Type: article

Abstract: Considerable purchase and maintenance costs of high-field NMR instruments restrict their applications in bio- and chemical laboratories. Benchtop spectrometers offer an affordable alternative, but are limited in their sensitivity and resolution. Herein, we demonstrate how parahydrogen based nh-PHIP hyperpolarization can be used to circumvent these hindrances, allowing to detect and resolve a mixture of dilute amino acids on an 80 MHz spectrometer.

Source: Chemical Communications

DOI: 10.1039/d5cc02870a

Authors: Mateusz Urbańczyk, Kärolin Kork, Kerti Ausmees, Tomasz Ratajczyk, Indrek Reile

Institutions: Institute of Physical Chemistry, Polish Academy of Sciences, National Institute of Chemical Physics and Biophysics

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green