Year: 2025
Type: article
Abstract: Cancer remains one of the leading causes of mortality worldwide. Despite recent advances, current chemotherapeutic options often have undesirable side effects, and the development of resistance limits their long-term effectiveness. The botanical kingdom contains a vast repository of phytochemicals with varying biological activities. This review examines the anticancer potential of various classes of plant bioactive compounds. Specific alkaloids like berberine demonstrate remarkable apoptosis induction through mitochondrial stress and caspase activation in numerous cancer cell lines. Curcumin modulates multiple oncogenic pathways, including PI3K/Akt, Wnt/β-catenin, and MAPK signaling. Resveratrol elicits favorable anti-tumor responses through intrinsic apoptosis, autophagy stimulation, and antiangiogenic effects. Promising preclinical studies have elucidated the underlying molecular mechanisms by which bioactive components such as quercetin, genistein, and epigallocatechin gallate exert chemopreventive effects. While intensive research is still required, progress in standardizing extracts, isolating marker compounds, and clinical testing validates nature's treasure as a source for novel anticancer options. Future studies should focus on overcoming translational barriers to move these promising compounds from bench to bedside.
Source: Futuristic Biotechnology
Authors: Hammad Ahmed Abbasi, Muhammad Atif, Muhammad Naveed Anjum, Jawad Ahmed, Abdul Wahab, Syed Ashman Ali Shah
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4412554022