Work

Inhibitory mechanism of pterostilbene and pinostilbene on aldose reductase and α-glucosidase: a new insight from inhibition kinetics and molecular docking studies

Year: 2025

Type: article

Abstract: = 1569 ± 177.858 μM) inhibition. Moreover, pinostilbene interacted with amino acid residues outside of aldose reductase and α-glucosidase active site to inhibit its activities by van der Waals, π-anion or π-alkyl interactions. The current study has provided comprehensive reference not only for the anti-diabetic mechanism of pterostilbene, but also offered a basis to develop and design adjuvant antidiabetic drugs or novel functional foods.

Source: RSC Advances

DOI: 10.1039/d5ra03002a

Authors: Lili Jiang, Yanyan Jia, Hang Yin, Yong Liu

Institution: Dalian University of Technology

Language: English

Topic: Aldose Reductase and Taurine

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042