Work

Appendicitis burden, trends, and inequalities in Europe, 1990–2019: a population-based study

Year: 2025

Type: article

Abstract: Background: Appendicitis imposes a substantial healthcare burden globally, yet comprehensive insights into its disease burden in Europe remain limited. This study assesses regional trends, disparities and high-burden countries for appendicitis in Europe. Methods: Data on appendicitis-related incidence, mortality and disability-adjusted life years (DALYs) were extracted from the Global Burden of Disease 2019 study. Joinpoint regression analyzed temporal trends, while health inequality and quadrant analyses identified socio-demographic disparities and priority countries. Results: In 2019, Europe's age-standardized incidence rate (ASIR) for appendicitis was 266.47 per 100,000, exceeding the global average (229.86 per 100,000). However, Europe's age-standardized mortality rate and age-standardized DALY rate were lower than the global averages. From 1990 to 2019, the average annual percentage change (AAPC) for the ASIR was 0.50%, whereas the AAPCs for the age-standardized mortality rate and age-standardized DALY rate were -3.02% and -2.20%, respectively. Finland was the sole exception, showing a reduced ASIR (AAPC: -0.20%). Health inequality analysis revealed that the burden of DALYs disproportionately affected less developed European nations. However, there was a notable improvement over the past three decades. The slope index of inequality decreased from -7.32 DALYs per 100,000 in 1990 to -1.02 DALYs per 100,000 in 2019, and the relative concentration index fell from -11.04 to -2.58 during the same period. Among the 43 countries, Bulgaria and Austria had the highest 2019 DALY burdens. Conclusions: Appendicitis persists as a critical public health challenge in Europe, necessitating targeted resource allocation and policy interventions in high-burden countries to address persistent health inequalities.

Source: Gastroenterology report

DOI: 10.1093/gastro/goaf070

Authors: Jun He, Meng-Dan Zhou, Yi-Dian Lei, Rong-Chao He, Zhong Shen, Xiu-Feng Zhang

Institutions: Third People's Hospital of Hangzhou, Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine

Language: English

Topic: Appendicitis Diagnosis and Management

Subfield: Emergency Medicine

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Reduced inequalities

Open Access status: gold

Estimated APC paid: $1,800