Work

Engineered acetylated inulin nanoparticles for enhanced oral insulin delivery: sustained release, structural stability, and in vivo efficacy

Year: 2025

Type: article

Abstract: , respectively. OGTT results showed that orally administered InAc-Ins nanoparticles reduced blood glucose levels more effectively than free insulin, achieving 42.8% of subcutaneous insulin efficacy. InAc nanoparticles offer effective protection and sustained release of insulin under gastrointestinal conditions, enhancing its structural integrity and hypoglycemic efficacy. This platform presents a promising strategy for non-invasive oral insulin delivery.

Source: RSC Advances

DOI: 10.1039/d5ra03627e

Authors: Achmad Ramadhanna'il Rasjava, Neng Fisheri Kurniati, Rukman Hertadi

Institutions: Bandung Institute of Technology, Lambung Mangkurat University

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042