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Dihydrotestosterone Remains Within Normal Range in Men Under Long Lasting Testosterone Therapy (TTh)

Year: 2025

Type: article

Abstract: The major goal of androgen therapy is to achieve testosterone levels as close to physiological concentrations as possible.For some androgen-dependent functions, testosterone is a pro-hormone, peripherally converted to 5a-dihydrotes-tosterone (DHT) and 17b-oestradiol of which the levels preferably should also be within their normal physiological ranges.In this study, the resulting plasma DHT levels in 122 hypogonadal men treated with a novel testosterone treatment modality: parenteral long-acting testosterone undecanoate (Nebido), were investigated.Following the treatment, there were no abnormally high/ low plasma DHT levels; levels varied between 86 and 511 ng l)1 (normal range:40-575 ng l).In conclusion, treatment with testosterone undecanoate generates physiological levels of DHT.Prostate safety parameters did not undergo changes.

Source: Medical & Clinical Case Reports Journal

DOI: 10.51219/mccrj/aksam-yassin/257

Authors: Aksam Yassin, Hatem Kamkoum, Dalia Alzubaidi, Rouda Almutawa, Mohamed Hatem, Anas Albudairat, Hasan Abdallah, Abdulla Al Ansari

Institutions: Hamad Medical Corporation, Weill Cornell Medical College in Qatar

Language: English

Topic: Hormonal and reproductive studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4412573169

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