Basal Cell Carcinoma Recurrence after Excision in a Patient with Complex Cardiac history: A Case Report
Year: 2025
Type: article
Study design: Case Report
Abstract: Basal cell carcinoma is a subtype of keratinocyte carcinoma; a non-melanoma skin cancer which occurs commonly in Caucasians, although it does occur with increased prevalence in Caucasians, patients with skin of color suffer from elevated morbidity and mortality when diagnosed with skin cancer.Extensive research has been established to identify the various mechanisms through which abnormal cell proliferation occurs in the human body; genetic mutations such as hedgehog signal pathway through which patched (PTCH) protein which function as a receptor and binds to the hedgehog receptor complex in the cell membrane have been directly instrumental in the pathogenesis of Basal cell carcinoma (BCC).There is also the indirect implication of ultraviolet DNA nucleotide changes in the tumor suppressor genes P53 and PTCH1 and mutations in the PTCH1 gene can lead to various cancers.Localized damage and disfigurement; BCC near the eyes, nose or ears can invade underlying structures making surgical removal more complicated and riskier.Lymphedema or swelling and cosmetic issues like loss of skin color, suture marks or excessive scarring are potential complications of surgery.Recurrence very frequently occurs even after successful removal excision.Patients may suffer from psychological issues resulting from pain, functional challenges and cosmetic concerns after treatment.
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4412573196