Oxidative stress modulation in type 2 diabetes: Insights from metformin and pioglitazone therapy
Year: 2025
Type: article
Abstract: This commentary critically examines a recent study that assessed the effects of metformin and pioglitazone on oxidative stress in patients with type 2 diabetes mellitus. The original study utilized multiple biomarkers such as IMA, TOS, TAS, and OSI but observed only limited antioxidant effects and a rise in IMA levels. By referencing additional clinical trials, experimental studies, and reviews, this commentary emphasizes the importance of using broader biomarker panels, extending treatment duration, and interpreting oxidative stress markers with caution in diabetes research.
Source: Journal of Medical Biochemistry
DOI: 10.5937/jomb0-59850
Author: Seshadri Varikasuvu
Institution: All India Institute of Medical Sciences, Deoghar
Language: English
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412587747