Work

Photophysical structured illumination velocimetry based on the long-lasting emission response of lanthanide luminescent nanoparticles

Year: 2025

Type: article

Abstract: This study introduces the concept of photophysical structured illumination velocimetry (PP-SIV), verified through comprehensive numerical simulations. PP-SIV can capture two-dimensional (2D) flow velocity fields from a single snapshot image of the emission pattern from luminescent probes, leveraging the suitable photodynamics of the probes and using the applied excitation field pattern as reference. By eliminating the need for any beam or sample scan, PP-SIV has the potential to significantly accelerate the data acquisition process required for velocity field imaging. Furthermore, with excitation patterns applied at different depths, three-dimensional (3D) flow imaging can be potentially achieved. We propose lanthanide-based upconversion nanoparticles (UCNPs), particularly those capable of both absorbing and emitting within the highly biocompatible and transparent NIR-II window (1000-1700 nm), as promising probe candidates for implementing PP-SIV. This concept holds significant potential to pave the way for rapid, three-dimensional (3D) blood flow imaging at sufficient speeds for real-time monitoring of hemodynamic events in the brain.

Source: Nanoscale Horizons

DOI: 10.1039/d5nh00395d

Authors: Haichun Liu, Jerker Widengren

Institution: KTH Royal Institute of Technology

Language: English

Topic: Luminescence Properties of Advanced Materials

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Funders: Stiftelsen för Strategisk Forskning, Stiftelsen Åforsk, Stiftelsen för Strategisk Forskning

Awards: G2953774785, G56912894, Bakteriella exosomer och deras nano-mimics som vaccin, G8581378045