Work

Design, synthesis and biological evaluation of novel bis(indolyl)-tetrazine derivatives as anti-breast cancer agents

Year: 2025

Type: article

Abstract: value of 1729 ± 24 nM when assessed for its affinity towards ER-α through a competitive ER-α binding assay. The Western blot analysis confirmed that compound 5b reduced the ER-α protein's expression, impeding its subsequent transactivation and signalling pathway within T-47D cells. Current findings imply that compound 5b, which exhibits significant ER-α antagonistic activity, can be a potential lead compound for developing anti-breast cancer agents.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d5md00297d

Authors: Kamalpreet Kaur, Harkomal Verma, Prabhakar Gangwar, Monisha Dhiman, Vikas Jaitak

Institution: Central University of Punjab

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Council of Scientific and Industrial Research, India