Work

Utility of microbial cell-free DNA sequencing in the diagnosis of mycobacterial infections in a quaternary care center

Year: 2025

Type: article

Abstract: We examine the performance of microbial cell-free DNA (mcfDNA) next-generation sequencing (NGS) testing on patients admitted to a quaternary care hospital in Houston, Texas. The test was 75.0% sensitive and 97.8% specific for all mycobacterial infections. mcfDNA NGS results led to adjustments in antimicrobial therapy for seven of nine patients with positive results.

Source: Antimicrobial Stewardship & Healthcare Epidemiology

DOI: 10.1017/ash.2025.10057

Authors: Fernando H. Centeno, Todd Lasco, Ahmed M. Hamdi, Mayar Al Mohajer

Institution: Baylor College of Medicine

Language: English

Topic: Bacterial Identification and Susceptibility Testing

Subfield: Clinical Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,719