Work

A comparative cost-benefit analysis of electronic brachytherapy vs. high-dose-rate iridium-192 for exclusive vaginal cuff treatment in post-operative endometrial cancer

Year: 2025

Type: article

Abstract: Purpose: Ir) brachytherapy for exclusive vaginal cuff treatment in post-operative endometrial cancer patients. Material and methods: for organs at risk (OARs), such as bladder, rectum, and sigmoid colon, were compared. Economic analysis focused solely on cost differences related to source replacement and maintenance, as all other procedural factors (i.e., personnel, clinical workflow, and logistics) were identical for both modalities. The cost of bunker was not considered in the analysis. Results: Ir, based on Spanish pricing, largely due to differences in source-related expenditures. Conclusions: Ir HDR remains the standard in brachytherapy due to its versatility, eBT presents a cost-benefit alternative for exclusive vaginal cuff treatments, particularly in settings where infrastructure limitations restrict isotope-based brachytherapy. These findings support the complementary role of eBT in clinical practice, optimizing resource allocation without compromising dosimetric quality.

Source: Journal of Contemporary Brachytherapy

DOI: 10.5114/jcb.2025.152539