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FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway

Year: 2025
Type: article
Abstract: The pathogenesis and chemoresistance mechanisms of colon cancer (CC) are still unclear. Here, we find that a long non-coding RNA (lncRNA), FEZ family zinc finger 1-antisense RNA 1 (FEZF1-AS1), is highly expressed in CC, which may be caused by the amplification mutation of FEZF1-AS1 at the gene level through bioinformatic analysis. FEZF1-AS1 has the potential to be a biomarker in the diagnosis of CC. Functionally, FEZF1-AS1 promotes the proliferation, invasion, metastasis, and survival of CC cells and reduces the sensitivity of CC cells to oxaliplatin. Mechanistically, FEZF1-AS1 drives autophagy-mediated development of CC and reduces chemosensitivity to oxaliplatin through inhabiting the PI3K/AKT/mTOR signaling pathway. In summary, our data suggest that FEZF1-AS1 may be a key driver of CC progression and chemotherapy resistance, and targeting FEZF1-AS1 may be a potential strategy for the diagnosis and treatment of CC.
DOI: 10.3389/fgene.2025.1514205
Authors: Xiaoping Yang, Zuohui Yuan, Lingzhu Gou, Long Cheng, Zirui Wang, Pingfan Wu, Xiaochun Wang, Xueni Ma, Tiantian Ma, Yi Yu, Zhiping Wu, Dekui Zhang
Institutions: Gansu Provincial Hospital, Lanzhou University Second Hospital, Lanzhou University, The No. 2 People's Hospital of Lanzhou, South China University of Technology, Xi'an Chest Hospital
Language: English
Subfield: Cancer Research
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4412646807
FWCI:
Cites: 87
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Related to: 10