Work

Solid-phase submonomer synthesis of sequence-defined oligothioetheramides

Year: 2025

Type: article

Abstract: Sequence-defined polymers have been developed using various orthogonal iterative chemical techniques. Among these, oligothioetheramides (OligoTEAs), which are designed with antimicrobial, cell-penetrating, and other biological properties, are synthesized through iterative solution-phase monomer addition on a soluble fluorous support. To simplify and streamline the iterative process, this work investigates the feasibility of an alternative submonomer solid-phase approach to oligoTEAs.

Source: Chemical Communications

DOI: 10.1039/d5cc02598b

Authors: Dana Abdullatif, Adithya Rangamani, Christopher A. Alabi

Institution: Cornell University

Language: English

Topic: Advanced Polymer Synthesis and Characterization

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: National Science Foundation, Cornell University, Saudi Aramco

Awards: MRI: Acquisition of a Cryogenic Probe and Modern Console for Outstanding NMR Sensitivity to Benefit Research and Education at Cornell University, Intracellular Processing of Cell-penetrating Oligothioetheramides