Thymoquinone prevents valproic acid-induced hepatotoxicity via modulation of cytochrome P450, PPARs, and apoptotic pathways.
Year: 2025
Type: article
Abstract: Objectives: L. and has anti-oxidant, anti-hepatotoxic, anti-cancer, anti-hypertensive, hypoglycemic, anti-inflammatory, and lipid-lowering properties. In this study, we investigated the protective properties of TQ on the cytochrome P450 enzyme system, peroxisome proliferator-activated receptors, and gene expressions involved in apoptosis, which are disrupted by valproic acid (VPA). Materials and Methods: The rats were put into control, VPA, and VPA+TQ groups. The weight of the body and liver were recorded. Liver tissue samples were evaluated for gene expressions (Bcl-2, p53, CYP2B1, CYP2B2, PPARα, and PPARγ), histopatology, and immunohistochemistry (CAS-3 and NOX-4). Additionally, serum was used to measure liver function parameters (ALT, AST, LDH, LDL, and HDL). Results: <0.0001). Conclusion: TQ substantially protects liver tissue by modifying gene expression, lowering oxidative stress, and increasing liver function. It significantly counteracts VPA's toxic effects, demonstrating its promise as a hepatoprotective agent in avoiding liver damage.
Source: PubMed
Authors: Sebile Azırak, Sedat Bilgiç, Deniz Taştemir Korkmaz, İlkay Armağan, Mehmet Özer Kaya
Institutions: Adıyaman University, Süleyman Demirel Üniversitesi
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Adiyaman Üniversitesi
OpenAlex ID: W4412650253